Title : Fluoxetine regulates glucose and lipid metabolism via the PI3K‑AKT signaling pathway in diabetic rats.

Pub. Date : 2020 Oct

PMID : 32945450






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1 Additionally, fluoxetine could inhibit the phosphatidylinositol 3-kinase-protein kinase B (PI3K-AKT) signaling pathway, whereas LY294002, a specific inhibitor of PI3K, suppressed the function of PI3K-AKT signaling and suppressed the expression levels of glucose metabolism-associated proteins, including GSK-3beta, G6PC, PEPCK and FOXO1 in BRL-3A cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one forkhead box O1 Rattus norvegicus