Pub. Date : 2021 Feb
PMID : 32940862
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Raloxifene inhibits pancreatic adenocarcinoma growth by interfering with ERbeta and IL-6/gp130/STAT3 signaling. | Raloxifene Hydrochloride | estrogen receptor 1 | Homo sapiens |
| 2 | Here, we hypothesized that raloxifene, a FDA-approved selective ER modulator (SERM), may suppress PDAC tumor growth by interfering with ERbeta signaling. | Raloxifene Hydrochloride | estrogen receptor 1 | Homo sapiens |
| 3 | Our results suggest that ERbeta signaling and IL-6/gp130 interaction may serve as promising drug targets for pancreatic cancer and that raloxifene may serve as an attractive therapeutic option for PDAC patients expressing the ERbeta isotype. | Raloxifene Hydrochloride | estrogen receptor 1 | Homo sapiens |