Title : Targeting phosphatidylinositol 3 kinase-β and -δ for Bruton tyrosine kinase resistance in diffuse large B-cell lymphoma.

Pub. Date : 2020 Sep 22

PMID : 32926124






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Reduced levels of BTK and enhanced phosphatidylinositol 3-kinase (PI3K)/AKT signaling were hallmarks of these ibrutinib-resistant cells. ibrutinib AKT serine/threonine kinase 1 Homo sapiens
2 Treatment with the selective PI3K-beta/delta dual inhibitor KA2237 reduced both tumorigenic properties and survival-based PI3K/AKT/mTOR signaling of these ibrutinib-resistant cells. ibrutinib AKT serine/threonine kinase 1 Homo sapiens
3 This study elucidates the compensatory upregulated PI3K/AKT axis that emerges in ibrutinib-resistant cells. ibrutinib AKT serine/threonine kinase 1 Homo sapiens