Title : Safety assessment of drug combinations used in COVID-19 treatment: in silico toxicogenomic data-mining approach.

Pub. Date : 2020 Nov 1

PMID : 32920000






3 Functional Relationships(s)
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Protein Name
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1 Chloroquine/hydroxychloroquine + azithromycin interacted with 6 genes (CCL2, CTSB, CXCL8, IL1B, IL6 and TNF), whereas chloroquine and azithromycin affected two additional genes (BCL2L1 and CYP3A4), which might be a reason behind a greater number of consequential diseases. Chloroquine tumor necrosis factor Homo sapiens
2 Chloroquine/hydroxychloroquine + azithromycin interacted with 6 genes (CCL2, CTSB, CXCL8, IL1B, IL6 and TNF), whereas chloroquine and azithromycin affected two additional genes (BCL2L1 and CYP3A4), which might be a reason behind a greater number of consequential diseases. Chloroquine tumor necrosis factor Homo sapiens
3 In contrast to lopinavir/ritonavir, chloroquine/hydroxychloroquine + azithromycin downregulated the expression of TNF and IL6. Chloroquine tumor necrosis factor Homo sapiens