Title : Calycosin inhibited autophagy and oxidative stress in chronic kidney disease skeletal muscle atrophy by regulating AMPK/SKP2/CARM1 signalling pathway.

Pub. Date : 2020 Oct

PMID : 32910538






3 Functional Relationships(s)
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1 Calycosin inhibited autophagy and oxidative stress in chronic kidney disease skeletal muscle atrophy by regulating AMPK/SKP2/CARM1 signalling pathway. 7,3'-dihydroxy-4'-methoxyisoflavone coactivator-associated arginine methyltransferase 1 Rattus norvegicus
2 Importantly, calycosin reduced autophagosome formation, down-regulated the expression of LC3A/B and ATG7 through inhibition of AMPK and FOXO3a, and increased SKP2, which resulted in decreased expression of CARM1, H3R17me2a. 7,3'-dihydroxy-4'-methoxyisoflavone coactivator-associated arginine methyltransferase 1 Rattus norvegicus
3 Our findings showed that calycosin inhibited oxidative stress and autophagy in CKD induced skeletal muscle atrophy and in TNF-alpha-induced C2C12 myotube atrophy, partially by regulating the AMPK/SKP2/CARM1 signalling pathway. 7,3'-dihydroxy-4'-methoxyisoflavone coactivator-associated arginine methyltransferase 1 Rattus norvegicus