Title : Regulation of expression and activity of the yeast transcription factor ADR1.

Pub. Date : 1988 May

PMID : 3290644






5 Functional Relationships(s)
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1 The expression of ADR1 mRNA and an ADR1-beta-galactosidase fusion protein during glucose repression suggested that the activity of the ADR1 protein is regulated at the posttranslational level to properly regulate ADH2 expression. Glucose DNA-binding transcription factor ADR1 Saccharomyces cerevisiae S288C
2 The expression of ADR1 mRNA and an ADR1-beta-galactosidase fusion protein during glucose repression suggested that the activity of the ADR1 protein is regulated at the posttranslational level to properly regulate ADH2 expression. Glucose DNA-binding transcription factor ADR1 Saccharomyces cerevisiae S288C
3 The expression of ADR1 mRNA and an ADR1-beta-galactosidase fusion protein during glucose repression suggested that the activity of the ADR1 protein is regulated at the posttranslational level to properly regulate ADH2 expression. Glucose DNA-binding transcription factor ADR1 Saccharomyces cerevisiae S288C
4 The ADR1-beta-galactosidase fusion protein was able to activate ADH2 expression during glucose repression but showed significantly higher levels of activation upon derepression. Glucose DNA-binding transcription factor ADR1 Saccharomyces cerevisiae S288C
5 These results suggest that low-level expression of ADR1 is required to maintain glucose repression of ADH2 and are consistent with the hypothesis that ADR1 is regulated at the posttranslational level. Glucose DNA-binding transcription factor ADR1 Saccharomyces cerevisiae S288C