Title : GANT61 and Lithium Chloride Inhibit the Growth of Head and Neck Cancer Cell Lines Through the Regulation of GLI3 Processing by GSK3β.

Pub. Date : 2020 Sep 3

PMID : 32899202






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 GANT61 and Lithium Chloride Inhibit the Growth of Head and Neck Cancer Cell Lines Through the Regulation of GLI3 Processing by GSK3beta. Lithium Chloride glycogen synthase kinase 3 alpha Homo sapiens
2 LiCl treatment increases the inhibitory Ser9 phosphorylation of the GSK3beta protein, leading to increased processing of GLI3 from full-length to repressor form, thus inhibiting HH-GLI pathway activity. Lithium Chloride glycogen synthase kinase 3 alpha Homo sapiens