Title : Kukoamine A Protects against NMDA-Induced Neurotoxicity Accompanied with Down-Regulation of GluN2B-Containing NMDA Receptors and Phosphorylation of PI3K/Akt/GSK-3β Signaling Pathway in Cultured Primary Cortical Neurons.

Pub. Date : 2020 Nov

PMID : 32892226






1 Functional Relationships(s)
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1 Additionally, pretreatment with KuA reversed NMDA-induced dephosphorylation of Akt and GSK-3beta and the protective effect of KuA on NMDA-induced cytotoxicity was abolished by wortmannin, a PI3K inhibitor. Wortmannin AKT serine/threonine kinase 1 Homo sapiens