Title : Synthesis and antitumor effects of novel 18β-glycyrrhetinic acid derivatives featuring an exocyclic α,β-unsaturated carbonyl moiety in ring A.

Pub. Date : 2020 Oct

PMID : 32890994






2 Functional Relationships(s)
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1 A series of novel 18beta-glycyrrhetinic acid (GA) derivatives featuring an exocyclic alpha,beta-unsaturated carbonyl moiety in ring A were synthesized and evaluated for their antitumor activities. 18alpha-glycyrrhetinic acid olfactory receptor family 2 subfamily F member 1B Mus musculus
2 Compounds 5c and 5l showed stronger cytotoxicity than other compounds and reported GA analogue CDODA-Me (methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate). 18alpha-glycyrrhetinic acid olfactory receptor family 2 subfamily F member 1B Mus musculus