Pub. Date : 2021 Mar
PMID : 32880929
13 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Molecular dynamics study with mutation shows that N-terminal domain (NTD) structural re-orientation in NPC1 is required for proper alignment of cholesterol transport. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 2 | The lysosomal membrane protein NPC1 (Niemann-Pick type C1) and NPC2 (Niemann-Pick type C2) are main players of cholesterol control in the lysosome and it is known that the mutation on these proteins leads to the cholesterol trafficking related neurodegenerative disease, which is called the Niemann-Pick disease type C (NPC) disease. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 3 | The lysosomal membrane protein NPC1 (Niemann-Pick type C1) and NPC2 (Niemann-Pick type C2) are main players of cholesterol control in the lysosome and it is known that the mutation on these proteins leads to the cholesterol trafficking related neurodegenerative disease, which is called the Niemann-Pick disease type C (NPC) disease. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 4 | The mutation R518W or R518Q on the NPC1 is one of type of disease-related mutation that causes cholesterol transports to be cut in half, which results in the accumulation of cholesterol and lipids in the late endosomal/lysosomal compartment of the cell. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 5 | The mutation R518W or R518Q on the NPC1 is one of type of disease-related mutation that causes cholesterol transports to be cut in half, which results in the accumulation of cholesterol and lipids in the late endosomal/lysosomal compartment of the cell. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 6 | Even though there has been significant progress with understanding the cholesterol transport by NPC1 in combination with NPC2, especially after the structural determination of the full length NPC1 in 2016, many details such as the interaction of the full length NPC1 with the NPC2, the molecular motions responsible for the cholesterol transport during and after this interaction, and the structure and the function relations of many mutations are still not well understood. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 7 | Even though there has been significant progress with understanding the cholesterol transport by NPC1 in combination with NPC2, especially after the structural determination of the full length NPC1 in 2016, many details such as the interaction of the full length NPC1 with the NPC2, the molecular motions responsible for the cholesterol transport during and after this interaction, and the structure and the function relations of many mutations are still not well understood. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 8 | Even though there has been significant progress with understanding the cholesterol transport by NPC1 in combination with NPC2, especially after the structural determination of the full length NPC1 in 2016, many details such as the interaction of the full length NPC1 with the NPC2, the molecular motions responsible for the cholesterol transport during and after this interaction, and the structure and the function relations of many mutations are still not well understood. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 9 | In this paper, we report the extensive molecular dynamics simulations in order to gain insight into the structure and the dynamics of NPC1 lumenal domain for the cholesterol transport and the disease behind the mutation (R518W). | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 10 | Also, the simulation indicates the possible re-orientation of the NTD with both the wild and the R518W mutated NPC1 after receiving the cholesterol from the NPC2, that align to form an internal tunnel, which is a possible pose for further action in cholesterol trafficking. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 11 | Also, the simulation indicates the possible re-orientation of the NTD with both the wild and the R518W mutated NPC1 after receiving the cholesterol from the NPC2, that align to form an internal tunnel, which is a possible pose for further action in cholesterol trafficking. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 12 | We believe the current study can provide a better understanding of the cholesterol transport by NPC1 especially the role of NTD of NPC1 in combination with NPC2 interactions. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 13 | We believe the current study can provide a better understanding of the cholesterol transport by NPC1 especially the role of NTD of NPC1 in combination with NPC2 interactions. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |