Title : Circulating bilirubin levels and risk of colorectal cancer: serological and Mendelian randomization analyses.

Pub. Date : 2020 Sep 3

PMID : 32878631






1 Functional Relationships(s)
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1 In the MR analysis of the main UGT1A1 SNP (rs6431625), genetically predicted higher levels of total bilirubin were associated with a 7% increase in CRC risk in men (OR = 1.07 (1.02-1.12); P = 0.006; per 1-SD increment of total bilirubin), while there was no association in women (OR = 1.01 (0.96-1.06); P = 0.73). Bilirubin UDP glucuronosyltransferase family 1 member A1 Homo sapiens