Title : Potential Doxorubicin-Mediated Dual-Targeting Chemotherapy in FANC/BRCA-Deficient Tumors via Modulation of Cellular Formaldehyde Concentration.

Pub. Date : 2020 Oct 19

PMID : 32876438






2 Functional Relationships(s)
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1 Using this strategy, DOX-mediated cytotoxicity in Fanconi anemia group gene (FANC)/breast cancer susceptibility gene (BRCA)-deficient cells increased up to 70-fold compared to that in cells proficient in DNA repair pathways by increasing intracellular formaldehyde (FA) concentration. Doxorubicin BRCA1 DNA repair associated Homo sapiens
2 Overall, anticancer therapy targeting tumors deficient in the FANC/BRCA pathway may be possible by minimizing DOX-induced toxicity in normal cells. Doxorubicin BRCA1 DNA repair associated Homo sapiens