Title : Venlafaxine protects against chronic stress-related behaviors in mice by activating the mTORC1 signaling cascade.

Pub. Date : 2020 Nov 1

PMID : 32871684






1 Functional Relationships(s)
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1 RESULT: Our results showed that the decreasing effects of CUMS and CSDS on the mTORC1 signaling cascade in the hippocampus and mPFC were restored by venlafaxine, and the use of rapamycin, LY294002, U0126 and mTORC1-shRNA fully abolished the anti-stress actions of venlafaxine in mice. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one CREB regulated transcription coactivator 1 Mus musculus