Title : Ligand with Two Modes of Interaction with the Dopamine D2 Receptor-An Induced-Fit Mechanism of Insurmountable Antagonism.

Pub. Date : 2020 Oct 7

PMID : 32865974






1 Functional Relationships(s)
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1 Here, we use G protein-coupled inward rectifier potassium (GIRK) channel activation in Xenopus oocytes to measure the kinetics of D2R antagonism by a series of aripiprazole analogues, as well as the recovery of dopamine (DA) responsivity upon washout. Dopamine potassium inwardly rectifying channel subfamily J member 3 S homeolog Xenopus laevis