Pub. Date : 2020 Sep
PMID : 32863204
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we show that in red cells Fyn specifically stimulates G6PD activity, resulting in a 3-fold increase enzyme catalytic activity (kcat) by phosphorylating tyrosine (Tyr)-401. | Tyrosine | FYN proto-oncogene, Src family tyrosine kinase | Homo sapiens |
| 2 | Here, we show that in red cells Fyn specifically stimulates G6PD activity, resulting in a 3-fold increase enzyme catalytic activity (kcat) by phosphorylating tyrosine (Tyr)-401. | Tyrosine | FYN proto-oncogene, Src family tyrosine kinase | Homo sapiens |
| 3 | We found Tyr-401 on G6PD as functional target of Fyn in normal human red blood cells (RBC), being undetectable in G6PD deficient RBCs (G6PD-Mediterranean and G6PD-Genova). | Tyrosine | FYN proto-oncogene, Src family tyrosine kinase | Homo sapiens |
| 4 | In conclusion, our data suggest that Fyn is an oxidative radical sensor, and that Fyn-mediated Tyr-401 phosphorylation, by increasing G6PD activity, plays an important role in the physiology of RBCs. | Tyrosine | FYN proto-oncogene, Src family tyrosine kinase | Homo sapiens |