Title : Breast Tumor Cell Invasion and Pro-Invasive Activity of Cancer-Associated Fibroblasts Co-Targeted by Novel Urokinase-Derived Decapeptides.

Pub. Date : 2020 Aug 24

PMID : 32847144






1 Functional Relationships(s)
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1 Specific binding of fluoresceinated Pep 2 to HT1080 and telomerase immortalised fibroblasts (TIF) cell surfaces was enhanced by alphav overexpression or abolished by excess vitronectin, anti-alphav antibodies or silencing of ITGAV alphav gene, identifying alphav-integrin as the Pep 2 molecular target. fluoresceinated vitronectin Homo sapiens