Title : Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma.

Pub. Date : 2021 Mar 18

PMID : 32842143






1 Functional Relationships(s)
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1 In order to explore this concept, we performed a c-Maf-recognition element-driven luciferase-based screen against FDA-approved drugs and natural products, from which the generic cardiac glycoside lanatoside C (LanC) is found to prevent c-Maf de-ubiquitination and induces its degradation by disrupting the interaction of Otub1 and c-Maf. lanatoside C OTU domain, ubiquitin aldehyde binding 1 Mus musculus