Title : The BCL-2 selective inhibitor ABT-199 sensitizes soft tissue sarcomas to proteasome inhibition by a concerted mechanism requiring BAX and NOXA.

Pub. Date : 2020 Aug 24

PMID : 32839432






2 Functional Relationships(s)
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1 The combination with BZB additionally resulted in the accumulation of BOK, a BAX/BAK homologue, and of the BH3-only protein NOXA, which inhibits the anti-apoptotic protein MCL-1. Bortezomib BCL2 associated X, apoptosis regulator Homo sapiens
2 This synergistic mechanism of action was verified by CRISPR/Cas9 knock-out, showing that both BAX and NOXA are crucial for ABT-199/BZB-induced apoptosis. Bortezomib BCL2 associated X, apoptosis regulator Homo sapiens