Pub. Date : 2020 Oct 15
PMID : 32835761
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Oxymatrine ameliorates imiquimod-induced psoriasis pruritus and inflammation through inhibiting heat shock protein 90 and heat shock protein 60 expression in keratinocytes. | oxymatrine | heat shock protein 1 (chaperonin) | Mus musculus |
| 2 | Molecular docking and the studies in vivo confirmed that HSP90 and HSP60 participate in the inhibitory effect of oxymatrine on the phenotypes of psoriasis mice. | oxymatrine | heat shock protein 1 (chaperonin) | Mus musculus |
| 3 | Mechanically, immunofluorescence staining demonstrated that oxymatrine-induced downregulation of HSP90 and HSP60 was mainly in keratinocytes. | oxymatrine | heat shock protein 1 (chaperonin) | Mus musculus |
| 4 | In vitro results showed that oxymatrine decreases the expression of HSP90 and HSP60 upregulated by TNF-alpha and IFN-gamma in HaCaTs cells and the siRNA mediated HSP90 and HSP60 silencing reverses inflammation inhibited by oxymatrine. | oxymatrine | heat shock protein 1 (chaperonin) | Mus musculus |
| 5 | In vitro results showed that oxymatrine decreases the expression of HSP90 and HSP60 upregulated by TNF-alpha and IFN-gamma in HaCaTs cells and the siRNA mediated HSP90 and HSP60 silencing reverses inflammation inhibited by oxymatrine. | oxymatrine | heat shock protein 1 (chaperonin) | Mus musculus |
| 6 | Taken together, these results indicate that oxymatrine relieves psoriasis pruritic and inflammation by inhibiting the expression of HSP90 and HSP60 in keratinocytes through MAPK signaling pathway. | oxymatrine | heat shock protein 1 (chaperonin) | Mus musculus |