Pub. Date : 2020
PMID : 32831998
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Short-Chain Fatty Acids Ameliorate Diabetic Nephropathy via GPR43-Mediated Inhibition of Oxidative Stress and NF-kappaB Signaling. | Fatty Acids, Volatile | free fatty acid receptor 2 | Mus musculus |
| 2 | Specifically, the beneficial effects of SCFAs were significantly facilitated by the overexpression GPR43 or imitated by a GPR43 agonist but were inhibited by siRNA-GPR43 in GMCs. | Fatty Acids, Volatile | free fatty acid receptor 2 | Mus musculus |
| 3 | Specifically, the beneficial effects of SCFAs were significantly facilitated by the overexpression GPR43 or imitated by a GPR43 agonist but were inhibited by siRNA-GPR43 in GMCs. | Fatty Acids, Volatile | free fatty acid receptor 2 | Mus musculus |
| 4 | Specifically, the beneficial effects of SCFAs were significantly facilitated by the overexpression GPR43 or imitated by a GPR43 agonist but were inhibited by siRNA-GPR43 in GMCs. | Fatty Acids, Volatile | free fatty acid receptor 2 | Mus musculus |
| 5 | These results support the conclusion that SCFAs, especially butyrate, partially improve T2D-induced kidney injury via GPR43-mediated inhibition of oxidative stress and NF-kappaB signaling, suggesting SCFAs may be potential therapeutic agents in the prevention and treatment of DN. | Fatty Acids, Volatile | free fatty acid receptor 2 | Mus musculus |
| 6 | These results support the conclusion that SCFAs, especially butyrate, partially improve T2D-induced kidney injury via GPR43-mediated inhibition of oxidative stress and NF-kappaB signaling, suggesting SCFAs may be potential therapeutic agents in the prevention and treatment of DN. | Fatty Acids, Volatile | free fatty acid receptor 2 | Mus musculus |