Title : Preclinical evidence that MNK/eIF4E inhibition by cercosporamide enhances the response to antiangiogenic TKI and mTOR inhibitor in renal cell carcinoma.

Pub. Date : 2020 Sep 10

PMID : 32828276






2 Functional Relationships(s)
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1 Mechanistically, we found that cercosporamide suppressed pro-angiogenic factors VEGF and HIFalpha, inhibited EMT and reduced pro-survival and cell cycle proteins; and furthermore this was attributed to cercosporamide"s ability in inhibiting eIF4E. cercosporamide vascular endothelial growth factor A Homo sapiens
2 Mechanistically, we found that cercosporamide suppressed pro-angiogenic factors VEGF and HIFalpha, inhibited EMT and reduced pro-survival and cell cycle proteins; and furthermore this was attributed to cercosporamide"s ability in inhibiting eIF4E. cercosporamide vascular endothelial growth factor A Homo sapiens