Pub. Date : 2020 Aug 19
PMID : 32825184
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | As a follow-up study of our previous findings, here we have identified that the pharmacological substances, leptomycin B and doxorubicin, can improve the sensitivity of cervical cancer cells to cisplatin inducing HP1gamma-mediated elevation of p53. | Doxorubicin | tumor protein p53 | Homo sapiens |
| 2 | We also found that doxorubicin, which induces the DNA damage response, promotes HP1gamma-mediated silencing of UBE2L3 and increases p53 stability. | Doxorubicin | tumor protein p53 | Homo sapiens |
| 3 | Doxorubicin sensitized the cisplatin-resistant cervical cancer cells, enhancing their p53 levels and rate of apoptosis when administered together with cisplatin. | Doxorubicin | tumor protein p53 | Homo sapiens |