Title : Enforced C-Src Activation Causes Compartmental Dysregulation of PI3K and PTEN Molecules in Lipid Rafts of Tongue Squamous Carcinoma Cells by Attenuating Rac1-Akt-GLUT-1-Mediated Sphingolipid Synthesis.

Pub. Date : 2020 Aug 13

PMID : 32823607






1 Functional Relationships(s)
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1 In conclusion, GA-induced c-Src activation is a key inductive event for the formation of inactive Rac1-p-CK2alpha (Tyr 255) complexes, which disturbed lipid raft compartment of PI3K and PTEN molecules by impairing Akt-regulated GLUT-1-mediated sphingolipid synthesis, and finally resulting in inhibition of TSC cell invasion. Tyrosine Rac family small GTPase 1 Homo sapiens