Title : A high throughput screen for TMPRSS2 expression identifies FDA-approved and clinically advanced compounds that can limit SARS-CoV-2 entry.

Pub. Date : 2020 Aug 14

PMID : 32818215






2 Functional Relationships(s)
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1 Among these, homoharringtonine and halofuginone appear the most potent agents, reducing endogenous TMPRSS2 expression at sub-micromolar concentrations. halofuginone transmembrane serine protease 2 Homo sapiens
2 We further demonstrate that halofuginone modulates TMPRSS2 levels through proteasomal-mediated degradation that involves the E3 ubiquitin ligase component DDB1- and CUL4-associated factor 1 (DCAF1). halofuginone transmembrane serine protease 2 Homo sapiens