Title : Deubiquitinase USP7-mediated MCL-1 up-regulation enhances Arsenic and Benzo(a)pyrene co-exposure-induced Cancer Stem Cell-like property and Tumorigenesis.

Pub. Date : 2020

PMID : 32802178






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Mechanistic studies revealed that arsenic plus BaP co-exposure up-regulates MCL-1 protein levels by synergistically activating the PI3K/Akt/mTOR pathway to increase the level of a deubiquitinase USP7, which in turn reduces the level of MCL-1 protein ubiquitination and prevents its subsequent proteasome degradation. Benzo(a)pyrene AKT serine/threonine kinase 1 Homo sapiens