Pub. Date : 2020 Oct 15
PMID : 32798557
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rapamycin improves renal injury induced by Iodixanol in diabetic rats by deactivating the mTOR/p70S6K signaling pathway. | Sirolimus | ribosomal protein S6 kinase B1 | Rattus norvegicus |
| 2 | Moreover, Rapamycin could inhibit the phosphorylation of mTOR/p70S6K pathway-associated proteins, activate autophagy and increase the levels of LC3 and Beclin1. | Sirolimus | ribosomal protein S6 kinase B1 | Rattus norvegicus |
| 3 | After treatment with 3MA, an inhibitor of mTOR/p70S6K signaling pathway, the protective effects of Rapamycin on CIAKI were weakened. | Sirolimus | ribosomal protein S6 kinase B1 | Rattus norvegicus |
| 4 | SIGNIFICANCE: Rapamycin can alleviate renal injury induced by Iodixanol diabetic rats, and its regulatory mechanisms may be related to the regulation of mTOR/p70S6K signaling pathway and the activating autophagy. | Sirolimus | ribosomal protein S6 kinase B1 | Rattus norvegicus |