Pub. Date : 2021 Mar
PMID : 32795530
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The p.Glu396Lys variant increased the enzymatic activity of PLCdelta1, leading to PKC/PKD/ERK1/2 pathway activation and TPRV6 channel closure, which not only resulted in excessive proliferation of keratinocytes in vitro and in vivo, but also induced local accumulation of calcium in the pilomatricoma-like tumor that developed spontaneously in the skin of Plcd1E396K/E396K mice. | Calcium | mitogen-activated protein kinase 3 | Mus musculus |