Title : Transient binding and jumping dynamics of p53 along DNA revealed by sub-millisecond resolved single-molecule fluorescence tracking.

Pub. Date : 2020 Aug 13

PMID : 32792545






4 Functional Relationships(s)
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1 We characterized the target search dynamics of the tumor suppressor p53 along nonspecific DNA at physiological salt concentrations. Salts tumor protein p53 Homo sapiens
2 Both the jumps and the one-dimensional diffusion of p53 along DNA were accelerated at higher salt concentrations, suggesting the rotation-uncoupled movement of p53 along DNA grooves and conformational changes in the p53/DNA complex. Salts tumor protein p53 Homo sapiens
3 Both the jumps and the one-dimensional diffusion of p53 along DNA were accelerated at higher salt concentrations, suggesting the rotation-uncoupled movement of p53 along DNA grooves and conformational changes in the p53/DNA complex. Salts tumor protein p53 Homo sapiens
4 Both the jumps and the one-dimensional diffusion of p53 along DNA were accelerated at higher salt concentrations, suggesting the rotation-uncoupled movement of p53 along DNA grooves and conformational changes in the p53/DNA complex. Salts tumor protein p53 Homo sapiens