Title : Identification and Preclinical Development of a 2,5,6-Trisubstituted Fluorinated Pyridine Derivative as a Radioligand for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors.

Pub. Date : 2020 Sep 24

PMID : 32787079






2 Functional Relationships(s)
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1 As part of our medicinal chemistry program, we have recently identified the pyridine-based CB2 PET radioligand [18F]3 with a binding affinity (Ki) of 6 nM for CB2 and a selectivity factor of 696 over the cannabinoid receptor type 1 (CB1). pyridine cannabinoid receptor 2 Rattus norvegicus
2 As part of our medicinal chemistry program, we have recently identified the pyridine-based CB2 PET radioligand [18F]3 with a binding affinity (Ki) of 6 nM for CB2 and a selectivity factor of 696 over the cannabinoid receptor type 1 (CB1). pyridine cannabinoid receptor 2 Rattus norvegicus