Title : Structural, in silico, and functional analysis of a Disabled-2-derived peptide for recognition of sulfatides.

Pub. Date : 2020 Aug 11

PMID : 32782308






3 Functional Relationships(s)
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1 Structural, in silico, and functional analysis of a Disabled-2-derived peptide for recognition of sulfatides. Sulfoglycosphingolipids DAB adaptor protein 2 Homo sapiens
2 Our previous research indicated that a 35-amino acid region within Dab2, which we refer to as the sulfatide-binding peptide (SBP), contains two potential sulfatide-binding motifs represented by two consecutive polybasic regions. Sulfoglycosphingolipids DAB adaptor protein 2 Homo sapiens
3 Using molecular docking, nuclear magnetic resonance, lipid-binding assays, and surface plasmon resonance, this work identifies the critical Dab2 residues within SBP that are responsible for sulfatide binding. Sulfoglycosphingolipids DAB adaptor protein 2 Homo sapiens