Pub. Date : 2020 Aug 6
PMID : 32781572
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Brain-Specific Serine-47 Modification of Cytochrome c Regulates Cytochrome c Oxidase Activity Attenuating ROS Production and Cell Death: Implications for Ischemia/Reperfusion Injury and Akt Signaling. | Reactive Oxygen Species | cytochrome c, somatic | Homo sapiens |
| 2 | Our results show that S47E Cytc results in partial inhibition of mitochondrial respiration corresponding with lower mitochondrial membrane potentials (DeltaPsim) and reduced reactive oxygen species (ROS) production. | Reactive Oxygen Species | cytochrome c, somatic | Homo sapiens |
| 3 | Our results show that S47E Cytc results in partial inhibition of mitochondrial respiration corresponding with lower mitochondrial membrane potentials (DeltaPsim) and reduced reactive oxygen species (ROS) production. | Reactive Oxygen Species | cytochrome c, somatic | Homo sapiens |
| 4 | When exposed to an oxygen-glucose deprivation/reoxygenation (OGD/R) model simulating ischemia/reperfusion injury, the Cytc S47E phosphomimetic cell line showed minimal ROS generation compared to the unphosphorylated WT Cytc cell line that generated high levels of ROS upon reoxygenation. | Reactive Oxygen Species | cytochrome c, somatic | Homo sapiens |
| 5 | When exposed to an oxygen-glucose deprivation/reoxygenation (OGD/R) model simulating ischemia/reperfusion injury, the Cytc S47E phosphomimetic cell line showed minimal ROS generation compared to the unphosphorylated WT Cytc cell line that generated high levels of ROS upon reoxygenation. | Reactive Oxygen Species | cytochrome c, somatic | Homo sapiens |
| 6 | Overall, our results suggest that loss of S47 phosphorylation of Cytc during brain ischemia drives reperfusion injury through maximal electron transport chain flux, DeltaPsim hyperpolarization, and ROS-triggered cell death. | Reactive Oxygen Species | cytochrome c, somatic | Homo sapiens |