Title : New coumarin-benzotriazole based hybrid molecules as inhibitors of acetylcholinesterase and amyloid aggregation.

Pub. Date : 2020 Oct 15

PMID : 32781220






1 Functional Relationships(s)
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1 13b (most potent AChE inhibitor) also showed copper-induced Abeta1-42 aggregation inhibition (34.26 % at 50 muMu) and chelating properties for metal ions (Cu2+, Fe2+, and Zn2+) involved in AD pathogenesis along with DNA protective potential against degenerative actions of OH radicals. cupric ion acetylcholinesterase (Cartwright blood group) Homo sapiens