Title : G-quadruplex-based aptamers targeting human thrombin: Discovery, chemical modifications and antithrombotic effects.

Pub. Date : 2021 Jan

PMID : 32777331






1 Functional Relationships(s)
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1 TBA - also named HD1, a 15-mer G-quadruplex (G4)-forming oligonucleotide - is the best characterized thrombin binding aptamer, able to specifically recognize the protein exosite I, thus inhibiting the conversion of soluble fibrinogen into insoluble fibrin strands. Oligonucleotides histone deacetylase 1 Homo sapiens