Title : Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity.

Pub. Date : 2020 Aug 6

PMID : 32759497






4 Functional Relationships(s)
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1 Here we show that low-dose RAD001/everolimus, an mTORC1 inhibitor, selectively targets mTORC1 signaling in endothelial cells (ECs) without affecting tumor cells or immune cells, resulting in tumor vessel normalization and increased antitumor immunity. Everolimus CREB regulated transcription coactivator 1 Mus musculus
2 Here we show that low-dose RAD001/everolimus, an mTORC1 inhibitor, selectively targets mTORC1 signaling in endothelial cells (ECs) without affecting tumor cells or immune cells, resulting in tumor vessel normalization and increased antitumor immunity. Everolimus CREB regulated transcription coactivator 1 Mus musculus
3 Here we show that low-dose RAD001/everolimus, an mTORC1 inhibitor, selectively targets mTORC1 signaling in endothelial cells (ECs) without affecting tumor cells or immune cells, resulting in tumor vessel normalization and increased antitumor immunity. Everolimus CREB regulated transcription coactivator 1 Mus musculus
4 Here we show that low-dose RAD001/everolimus, an mTORC1 inhibitor, selectively targets mTORC1 signaling in endothelial cells (ECs) without affecting tumor cells or immune cells, resulting in tumor vessel normalization and increased antitumor immunity. Everolimus CREB regulated transcription coactivator 1 Mus musculus