Pub. Date : 2020 Sep
PMID : 32755412
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Brain Testosterone-CYP1B1 (Cytochrome P450 1B1) Generated Metabolite 6beta-Hydroxytestosterone Promotes Neurogenic Hypertension and Inflammation. | Testosterone | cytochrome P450, family 1, subfamily b, polypeptide 1 | Mus musculus |
| 2 | Brain Testosterone-CYP1B1 (Cytochrome P450 1B1) Generated Metabolite 6beta-Hydroxytestosterone Promotes Neurogenic Hypertension and Inflammation. | Testosterone | cytochrome P450, family 1, subfamily b, polypeptide 1 | Mus musculus |
| 3 | Previously, we showed that peripheral administration of 6beta-hydroxytestosterone, a CYP1B1 (cytochrome P450 1B1)-generated metabolite of testosterone, promotes angiotensin II-induced hypertension in male mice. | Testosterone | cytochrome P450, family 1, subfamily b, polypeptide 1 | Mus musculus |
| 4 | Previously, we showed that peripheral administration of 6beta-hydroxytestosterone, a CYP1B1 (cytochrome P450 1B1)-generated metabolite of testosterone, promotes angiotensin II-induced hypertension in male mice. | Testosterone | cytochrome P450, family 1, subfamily b, polypeptide 1 | Mus musculus |
| 5 | This study was conducted to determine whether testosterone-CYP1B1 generated metabolite 6beta-hydroxytestosterone locally in the brain promotes the effect of systemic angiotensin II to produce hypertension in male mice. | Testosterone | cytochrome P450, family 1, subfamily b, polypeptide 1 | Mus musculus |
| 6 | These data suggest that testosterone-CYP1B1-generated metabolite 6beta-hydroxytestosterone, most likely in the paraventricular nucleus via AR and GPRC6A, contributes to angiotensin II-induced hypertension and neuroinflammation in male mice. | Testosterone | cytochrome P450, family 1, subfamily b, polypeptide 1 | Mus musculus |