Pub. Date : 2020 Aug 2
PMID : 32748870
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In a PAN-NET cell line, metformin did not affect Akt phosphorylation; conversely, it significantly decreased Akt phosphorylation in a PNT cell line. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Using everolimus-resistant NET cells, we confirmed that metformin maintained its effects, acting by two different pathways: Akt-dependent or independent, depending on the cell type, with both leading to mTOR suppression. | Metformin | AKT serine/threonine kinase 1 | Homo sapiens |