Pub. Date : 2020 Oct
PMID : 32738596
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Anti-arthritis effect of berberine associated with regulating energy metabolism of macrophages through AMPK/ HIF-1alpha pathway. | Berberine | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |
| 2 | Meanwhile, we found BBR up-regulated the expression of AMP-activated protein kinase phosphorylation (p-AMPK) and down-regulated the expression of Hypoxia inducible factor 1alpha (HIF-1alpha) in synovial macrophages of AA rats. | Berberine | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |
| 3 | In vitro, using LPS-stimulated peritoneal macrophages from normal rats, we also verified that pretreatment with BBR promoted transition from M1 to M2 by up-regulating the expression of p-AMPK and suppressing the expression of HIF-1alpha. | Berberine | protein kinase AMP-activated catalytic subunit alpha 2 | Rattus norvegicus |