Title : A thermostable, closed SARS-CoV-2 spike protein trimer.

Pub. Date : 2020 Oct

PMID : 32737467






3 Functional Relationships(s)
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1 Here we have designed mutations in S that allow the production of thermostable, disulfide-bonded S-protein trimers that are trapped in the closed, prefusion state. Disulfides surface glycoprotein Severe acute respiratory syndrome coronavirus 2
2 Structures of the disulfide-stabilized and non-disulfide-stabilized proteins reveal distinct closed and locked conformations of the S trimer. Disulfides surface glycoprotein Severe acute respiratory syndrome coronavirus 2
3 Structures of the disulfide-stabilized and non-disulfide-stabilized proteins reveal distinct closed and locked conformations of the S trimer. Disulfides surface glycoprotein Severe acute respiratory syndrome coronavirus 2