Title : Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53's DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption.

Pub. Date : 2020 Jul 25

PMID : 32722430






5 Functional Relationships(s)
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1 Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53"s DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption. Arecoline tumor protein p53 Homo sapiens
2 Previously, we have reported that arecoline (0.3 mM) is able to inhibit DNA repair in a p53-dependent pathway, but the underlying mechanism is unclear. Arecoline tumor protein p53 Homo sapiens
3 Here we demonstrated that arecoline suppressed the expression of DDB2, which is transcriptionally regulated by p53 and is required for nucleotide excision repair (NER). Arecoline tumor protein p53 Homo sapiens
4 Mechanistically, arecoline inhibited p53-induced DDB2 promoter activity through the DNA-binding but not the transactivation domain of p53. Arecoline tumor protein p53 Homo sapiens
5 These data uncover one of mechanisms underlying arecoline-mediated carcinogenicity through inhibiting p53-regulated DDB2 expression and DNA repair. Arecoline tumor protein p53 Homo sapiens