Pub. Date : 2020 Jul 25
PMID : 32722430
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Downregulation of the DNA Repair Gene DDB2 by Arecoline Is through p53"s DNA-Binding Domain and Is Correlated with Poor Outcome of Head and Neck Cancer Patients with Betel Quid Consumption. | Arecoline | tumor protein p53 | Homo sapiens |
2 | Previously, we have reported that arecoline (0.3 mM) is able to inhibit DNA repair in a p53-dependent pathway, but the underlying mechanism is unclear. | Arecoline | tumor protein p53 | Homo sapiens |
3 | Here we demonstrated that arecoline suppressed the expression of DDB2, which is transcriptionally regulated by p53 and is required for nucleotide excision repair (NER). | Arecoline | tumor protein p53 | Homo sapiens |
4 | Mechanistically, arecoline inhibited p53-induced DDB2 promoter activity through the DNA-binding but not the transactivation domain of p53. | Arecoline | tumor protein p53 | Homo sapiens |
5 | These data uncover one of mechanisms underlying arecoline-mediated carcinogenicity through inhibiting p53-regulated DDB2 expression and DNA repair. | Arecoline | tumor protein p53 | Homo sapiens |