Pub. Date : 2020
PMID : 32714568
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In an effort to understand MLN4924-induced cell death in CRC, we identified p53 as an important mediator of the apoptotic response to MLN4924. | pevonedistat | tumor protein p53 | Homo sapiens |
| 2 | In an effort to understand MLN4924-induced cell death in CRC, we identified p53 as an important mediator of the apoptotic response to MLN4924. | pevonedistat | tumor protein p53 | Homo sapiens |
| 3 | Depletion of the anti-apoptotic protein FLIP, which we identify as a novel mediator of resistance to MLN4924, enhanced apoptosis in a p53-, TRAIL-R2/DR5-, and caspase-8-dependent manner. | pevonedistat | tumor protein p53 | Homo sapiens |
| 4 | The cell death induced by MLN4924/SN38 combination was dependent on activation of mitochondria through BAX/BAK, but in a p53-independent manner, an important observation given the high frequency of TP53 mutation(s) in advanced CRC. | pevonedistat | tumor protein p53 | Homo sapiens |
| 5 | The cell death induced by MLN4924/SN38 combination was dependent on activation of mitochondria through BAX/BAK, but in a p53-independent manner, an important observation given the high frequency of TP53 mutation(s) in advanced CRC. | pevonedistat | tumor protein p53 | Homo sapiens |