Pub. Date : 2020
PMID : 32714145
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study aims to investigate the effects of long non-coding RNA LINC00641 on the ketamine-induced neural injury. | Ketamine | long intergenic non-protein coding RNA 641 | Homo sapiens |
| 2 | Ketamine-induced aberrant expression levels of LINC00641, miR-497-5p and brain-derived neurotrophic factor (BDNF) were examined by qRT-PCR. | Ketamine | long intergenic non-protein coding RNA 641 | Homo sapiens |
| 3 | Results: Ketamine induced the apoptosis of PC12 cells, accompanied by down-regulation of LINC00641 and BDNF, and up-regulation of miR-497-5p. | Ketamine | long intergenic non-protein coding RNA 641 | Homo sapiens |
| 4 | Conclusion: Collectively, LINC00641/miR-497-5p/BDNF axis was validated to be an important signaling pathway in modulating ketamine-induced neural injury. | Ketamine | long intergenic non-protein coding RNA 641 | Homo sapiens |