Pub. Date : 2020 Jul 1
PMID : 32711417
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ERCC1, XRCC1, and GSTP1 Polymorphisms and Treatment Outcomes of Advanced Epithelial Ovarian Cancer Patients Treated with Platinum-based Chemotherapy. | Platinum | ERCC excision repair 1, endonuclease non-catalytic subunit | Homo sapiens |
| 2 | Methods: We conducted the study to investigate the association between polymorphisms of ERCC1, XRCC1 and GSTP1, which responsible for platinum"s metabolisms in Thai epithelial ovarian cancer patients. | Platinum | ERCC excision repair 1, endonuclease non-catalytic subunit | Homo sapiens |
| 3 | Patients with homozygous variant type (A/A) of ERCC1 C8092A had higher rate of platinum-resistance (75% vs 16.7%, p =0.046). | Platinum | ERCC excision repair 1, endonuclease non-catalytic subunit | Homo sapiens |
| 4 | CONCLUSIONS: Genetic polymorphisms of ERCC1, and GSTP1 might be useful biomarkers for prediction of clinical benefit and toxicities of platinum-based chemotherapy in Thai epithelial ovarian cancer patients.<br />. | Platinum | ERCC excision repair 1, endonuclease non-catalytic subunit | Homo sapiens |