Pub. Date : 2020 Jul 17
PMID : 32709019
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CD38, a major mammalian NAD+ glycohydrolase (NADase), expresses on T cells following activation and appears to be an essential modulator of intracellular NAD+ levels. | NAD | CD38 molecule | Homo sapiens |
| 2 | The enzymatic activity of CD38 in the process of generating the second messenger cADPR utilizes intracellular NAD+, and thus limits its availability to different NAD+ consuming enzymes (PARP, ART, and sirtuins) inside the cells. | NAD | CD38 molecule | Homo sapiens |
| 3 | The enzymatic activity of CD38 in the process of generating the second messenger cADPR utilizes intracellular NAD+, and thus limits its availability to different NAD+ consuming enzymes (PARP, ART, and sirtuins) inside the cells. | NAD | CD38 molecule | Homo sapiens |
| 4 | The present review discusses how the CD38-NAD+ axis affects T cell activation and differentiation through interfering with their signaling and metabolic processes. | NAD | CD38 molecule | Homo sapiens |
| 5 | We also describe the pivotal role of the CD38-NAD+ axis in influencing the chromatin remodeling and rewiring T cell response. | NAD | CD38 molecule | Homo sapiens |
| 6 | Overall, this review emphasizes the crucial contribution of the CD38-NAD+ axis in altering T cell response in various pathophysiological conditions. | NAD | CD38 molecule | Homo sapiens |