Pub. Date : 2020 Jul 22
PMID : 32707767
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The CPA-induced bladder pain was abolished by pharmacological inhibition of T-type Ca2+ channels or CSE, and genetic deletion of Cav3.2. | Cyclophosphamide | calcium channel, voltage-dependent, T type, alpha 1H subunit | Mus musculus |
| 2 | Together, our data suggest that CPA, once metabolized to acrolein, causes urothelial ATP-mediated, redox-dependent HMGB1 release from macrophages, which in turn causes RAGE-mediated CSE upregulation and subsequent H2S-targeted Cav3.2-dependent nociceptor excitation, resulting in bladder pain. | Cyclophosphamide | calcium channel, voltage-dependent, T type, alpha 1H subunit | Mus musculus |