Pub. Date : 2020 Oct
PMID : 32707154
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Hepcidin is a peptide that regulates systemic iron metabolism by interacting with iron exporter ferroportin 1 (FPN1). | Iron | hepcidin antimicrobial peptide | Mus musculus |
2 | Hepcidin is a peptide that regulates systemic iron metabolism by interacting with iron exporter ferroportin 1 (FPN1). | Iron | hepcidin antimicrobial peptide | Mus musculus |
3 | Studies have indicated that the astrocyte hepcidin could regulate brain iron intake at the blood-brain barrier and injection of hepcidin into brain attenuated iron deposition in the brain. | Iron | hepcidin antimicrobial peptide | Mus musculus |
4 | However, whether overexpression of hepcidin in astrocytes of APP/PS1 transgenic mice can alleviate AD symptoms by reducing iron deposition has not been evaluated. | Iron | hepcidin antimicrobial peptide | Mus musculus |
5 | Further investigations revealed that overexpression of hepcidin in astrocytes significantly reduced iron levels in cortex and hippocampus of APP/PS1 mice, especially iron content in neurons, which led to the reduction of iron accumulation-induced oxidative stress and neuroinflammation, and finally decreased neuronal cell death in the cortex and hippocampus of APP/PS1 mice. | Iron | hepcidin antimicrobial peptide | Mus musculus |
6 | Further investigations revealed that overexpression of hepcidin in astrocytes significantly reduced iron levels in cortex and hippocampus of APP/PS1 mice, especially iron content in neurons, which led to the reduction of iron accumulation-induced oxidative stress and neuroinflammation, and finally decreased neuronal cell death in the cortex and hippocampus of APP/PS1 mice. | Iron | hepcidin antimicrobial peptide | Mus musculus |
7 | Further investigations revealed that overexpression of hepcidin in astrocytes significantly reduced iron levels in cortex and hippocampus of APP/PS1 mice, especially iron content in neurons, which led to the reduction of iron accumulation-induced oxidative stress and neuroinflammation, and finally decreased neuronal cell death in the cortex and hippocampus of APP/PS1 mice. | Iron | hepcidin antimicrobial peptide | Mus musculus |