Pub. Date : 2020 Jul 14
PMID : 32699853
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show that SARS-CoV-2 spike protein interacts with cell surface heparan sulfate and angiotensin converting enzyme 2 (ACE2) through its Receptor Binding Domain. | Heparitin Sulfate | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 2 | Contrary to studies with purified components, spike protein binding to heparan sulfate and ACE2 on cells occurs codependently. | Heparitin Sulfate | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 3 | Unfractionated heparin, non-anticoagulant heparin, treatment with heparin lyases, and purified lung heparan sulfate potently block spike protein binding and infection by spike protein-pseudotyped virus and SARS-CoV-2 virus. | Heparitin Sulfate | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
| 4 | Unfractionated heparin, non-anticoagulant heparin, treatment with heparin lyases, and purified lung heparan sulfate potently block spike protein binding and infection by spike protein-pseudotyped virus and SARS-CoV-2 virus. | Heparitin Sulfate | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |