Pub. Date : 2020
PMID : 32692762
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer. | Mevalonic Acid | 3-hydroxy-3-methylglutaryl-CoA synthase 1 | Homo sapiens |
| 2 | When detailing the mevalonate pathway in breast cancer using a single-cell qPCR, we identified the mevalonate precursor enzyme, HMGCS1, as a specific marker of CSC-enriched subpopulations within both luminal and basal tumour subtypes. | Mevalonic Acid | 3-hydroxy-3-methylglutaryl-CoA synthase 1 | Homo sapiens |
| 3 | When detailing the mevalonate pathway in breast cancer using a single-cell qPCR, we identified the mevalonate precursor enzyme, HMGCS1, as a specific marker of CSC-enriched subpopulations within both luminal and basal tumour subtypes. | Mevalonic Acid | 3-hydroxy-3-methylglutaryl-CoA synthase 1 | Homo sapiens |
| 4 | Taken together, this study highlights HMGCS1 as a potential gatekeeper for dysregulated mevalonate metabolism important for CSC-features in both luminal and basal breast cancer subtypes. | Mevalonic Acid | 3-hydroxy-3-methylglutaryl-CoA synthase 1 | Homo sapiens |