Title : Nonesterified free fatty acids enhance the inflammatory response in renal tubules by inducing extracellular ATP release.

Pub. Date : 2020 Aug 1

PMID : 32686520






1 Functional Relationships(s)
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1 Furthermore, extracellular ATP aggravates PA-induced monocyte chemoattractant protein-1 secretion and monocyte infiltration of tubular cells, enlarging the inflammatory response in both macrophages and HK-2 cells via the purinergic P2X7 receptor-mammalian target of rapamycin-forkhead box O1-thioredoxin-interacting protein/NOD-like receptor protein 3 inflammasome pathway. Palmitic Acid C-C motif chemokine ligand 2 Homo sapiens