Pub. Date : 2020 Sep 15
PMID : 32682918
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ginkgolide-A attenuates bacterial translocation through activating PXR and improving antimicrobial peptide Reg 3A in experimental cirrhosis. | ginkgolide A | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 2 | We previously showed that Ginkgolide-A (GA), a natural PXR ligand, attenuated BT in cirrhotic mice by abrogating inflammation along the gut-liver-axis, and by protecting small intestinal tight junctions (TJ). | ginkgolide A | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 3 | We previously showed that Ginkgolide-A (GA), a natural PXR ligand, attenuated BT in cirrhotic mice by abrogating inflammation along the gut-liver-axis, and by protecting small intestinal tight junctions (TJ). | ginkgolide A | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 4 | Here, we aimed to investigate the effect of GA in activating PXR and associated antimicrobial peptides (AMPs) in regulating BT in experimental cirrhosis. | ginkgolide A | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 5 | CONCLUSION: The study showed for the first time that, GA treatment to cirrhotic rodents attenuates BT, by improving PXR and Reg3A expression. | ginkgolide A | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |