Title : Regulation of the aryl hydrocarbon receptor activity in bovine cumulus-oocyte complexes during in vitro maturation: The role of EGFR and post-EGFR ERK1/2 signaling cascade.

Pub. Date : 2020 Oct 15

PMID : 32679457






1 Functional Relationships(s)
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1 Blocking ERK1/2 signaling in COCs during IVM with the specific EGFR inhibitor AG1478 or the mitogen-activated protein kinase kinase (MEK) inhibitor PD98059 downregulated the expression of the AhR-target gene Cyp1a1. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one cytochrome P450 1A1 Bos taurus